Clarithromycin is an antibiotic. It's used to treat chest infections, such as pneumonia, skin problems such as cellulitis, and ear infections. It's also used to get rid of Helicobacter pylori, a bacteria that can cause stomach ulcers. Clarithromycin is a macrolide antibiotic. It fights bacteria in your body. Clarithromycin is used to treat many different types of bacterial infections affecting the skin and respiratory system.