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Orlistat, the active component of generic Xenical, is a prescription drug used to control weight. By acting as a lipase inhibitor, it lowers dietary fat absorption by about 30%. Orlistat works by inhibiting the digestive enzyme lipase, which stops fat from being broken down and absorbed, causing it to be expelled in the stools. When combined with a low-fat, low-calorie diet and frequent exercise, this mechanism aids in weight loss and maintenance.